In Excess Vitamin B6 Causes Sensory Neuropathy

The development of sensory neuropathy has been reported in patients taking 2-7 g of pyridoxine per day for a variety of reasons (there is some slight evidence that it is effective in treating premenstrual syndrome). There was some residual damage after withdrawal of these high doses; other reports suggest that intakes in excess of 200 mg/d are associated with neurologic damage.

HOCH,

CHpOH i 2

N CH3 Pyridoxine

Pyridoxal

CH2NH2

hoch,

Pyridoxamine

Figure 45-12.

vitamers.

KINASE

i ch2oh

O POCH

\phosphatasE 0 vxch

Pyridoxine phosphate

OXIDASE

KINASE

PHOSPHATASE O"

Pyridoxal phosphate

AMINOTRANSFERASES

OXIDASE

KINASE

Phosphatase o o"

CH2NH2

Pyridoxamine phosphate

Interconversion of the vitamin B6

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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