twenty-sixth edition

Robert K. Murray, MD, PhD

Professor (Emeritus) of Biochemistry University of Toronto Toronto, Ontario

Daryl K. Granner, MD

Joe C. Davis Professor of Biomedical Science

Director, Vanderbilt Diabetes Center

Professor of Molecular Physiology and Biophysics and of Medicine

Vanderbilt University

Nashville, Tennessee

Peter A. Mayes, PhD, DSc

Emeritus Professor of Veterinary Biochemistry Royal Veterinary College University of London London

Victor W. Rodwell, PhD

Professor of Biochemistry Purdue University West Lafayette, Indiana

Lange Medical Books/McGraw-Hill

Medical Publishing Division

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The McGraw-Hill Companies

Harper's Illustrated Biochemistry, Twenty-Sixth Edition

Copyright © 2003 by The McGraw-Hill Companies, Inc. All rights reserved. Printed in the United States of America. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a data base or retrieval system, without the prior written permission of the publisher.

Previous editions copyright © 2000, 1996, 1993, 1990 by Appleton & Lange; copyright © 1988 by Lange Medical Publications.

234567890 DOC/DOC 09876543

ISBN 0-07-138901-6 ISSN 1043-9811


Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. The authors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication. However, in view of the possibility of human error or changes in medical sciences, neither the authors nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of the information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information sheet included in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs.

This book was set in Garamond by Pine Tree Composition

The editors were Janet Foltin, Jim Ransom, and Janene Matragrano Oransky.

The production supervisor was Phil Galea.

The illustration manager was Charissa Baker.

The text designer was Eve Siegel.

The cover designer was Mary McKeon.

The index was prepared by Kathy Pitcoff.

RR Donnelley was printer and binder.

This book is printed on acid-free paper.

ISBN-0-07-121766-5 (International Edition)

Copyright © 2003. Exclusive rights by the McGraw-Hill Companies, Inc., for manufacture and export. This book cannot be re-exported from the country to which it is consigned by McGraw-Hill. The International Edition is not available in North America.


Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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