Demyelinating

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Multiple sclerosis (MS), like head trauma, is more frequently encountered as a cause of dementia when younger populations are studied. MS has its peak onset in the third and fourth decades of life and is more common in women than men by 2:1. The risk of MS is significantly higher among those raised in latitudes farther from the equator, particularly for the Northern Hemisphere (Kurtzke, 1985). As with alcoholism, neuropsychological impairment may be detected in 50% of persons with MS, but fewer than 10% have frank dementia (Halligan, Reznikoff, Friedman, & LaRocca, 1988).

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