Anti-inflammatory/immunosuppressant: 0.121.7 mg/kg/day IV/IM/PO in divided doses every 612 hrs; pulse therapy: 15-30 mg/kg/day once daily for 3 days.
Status asthmaticus: load 2 mg/kg IV, then 1 mg/kg/dose every 6 hrs.
Acute spinal cord injury: 30 mg/kg IV over 15 minutes, followed in 45 minutes by a continuous infusion of 5.4 mg/kg/hr for 23 hrs. Clearance: hepatic metabolism; renal elimination. Contraindications: serious infections except septic shock or tuberculous meningitis. Adverse effects: may cause hypertension, pseudotumor cerebri, acne, Cushing's syndrome, adrenal axis suppression, GI bleeding, hyperglycemia, and osteoporosis. Comments: use caution in hyperthyroidism, cirrhosis, nonspecific ulcerative colitis, hypertension, osteoporosis, thromboembolic tendencies, CHF, convulsive disorders, myasthenia gravis, thrombophlebitis, peptic ulcer, diabetes.
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