Classification Of Disease Models

The majority of laboratory animal models are developed and used to study the cause, nature, and cure of human disorders. They may conveniently be categorized in one of the following five groups, of which the three first are the most important, as given in numerical order 1. Induced (experimental) disease models 2. Spontaneous (genetic) disease models Induced (Experimental) Disease Models As the name implies, induced models are healthy animals in which the condition to be investigated is...

The Concept Of Animal Models

A model is an object of imitation, something that accurately resembles something else, a person or thing that is the likeness or image of another.4 Prometheus, who has been deigned by poets to have first formed Man, formed a model from water and earth and then stole fire from the sun to animate the model.5 An animal model is thus an animated object of imitation in the image of humans (or other species), used to investigate biological or pathobiological phenomena. A laboratory animal model...

References

Coffey, D.S. and Isaacs, J.T., Requirements for an idealized animal model in prostatic cancer, in Models for Prostate Cancer, Murphy, G.R, Ed., Alan R. Liss, New York, 1980, 379. 2. Held, J.R., Muhlbock Memorial Lecture considerations in the provision and characterization of animal models, in Animal Quality and Models in Biomedical Research, 7th ICLAS Symposium Utrecht 1979, Spiegel, A., Erichsen, S., and Solleveld, H.A., Eds., Gustav Fisher Verlag, 1980. 3. Loew, F.M., Scholarship and clinical...

About the Editors

Jann Hau is Professor of Comparative Medicine at the University of Uppsala in Sweden. Dr. Hau graduated in experimental biology from University of Odense in Denmark after medical and biology studies in 1977, and specialized in laboratory animal science. Following research fellowships at University of Odense, he did his doctorate (Dr. Med.) at this university. In 1983, he joined the Department of Pathology at The Royal Veterinary and Agricultural University (RVAU) in Copenhagen as Associate...